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• Batch tested Purity: ≥ 99 % (HPLC / SEC, typical)
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ARA-290

Synonyms / Designations: ARA-290, Cibinetide, Helix B Surface Peptide (HBSP), Erythropoietin-derived peptide
CAS Number: 1208243-50-8
Molecular Formula: C51H84N16O21
Molar Weight: 1257.3 g/mol
Peptide Sequence: Derived from the helix B region of erythropoietin (EPO)
Peptide Classification: Synthetic peptide analogue; tissue-protective EPO-derived peptide
Purity: ≥ 99 % (HPLC / SEC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 10 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

ARA-290 is a synthetic peptide derived from the helix B domain of erythropoietin, designed to selectively activate the innate repair receptor (IRR) without stimulating classical erythropoietic pathways. It was developed as a structurally defined research tool to investigate cytoprotective and anti-inflammatory signalling mechanisms independent of red blood cell production.

In biochemical and cellular research systems, ARA-290 interacts with the EPOR–CD131 receptor complex, initiating intracellular signalling cascades associated with cellular stress responses, inflammation modulation, and tissue protection. Experimental studies examine receptor selectivity, downstream signalling pathways, and comparative responses relative to full-length erythropoietin. Observed molecular effects are dependent on experimental design, concentration, and model system, and are used to explore signalling mechanisms rather than defined biological or physiological outcomes.

Applications in Research

• Investigation of tissue-protective and cytoprotective signalling pathways
• Study of EPOR–CD131 receptor-mediated intracellular signalling
• In vitro models examining inflammatory and stress-response mechanisms
• Use as a reference compound in erythropoietin-derived peptide research

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution
• Avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at –20 °C (or lower)
• Avoid repeated freeze–thaw cycles

Specifications Summary

Purity: Manufactured to specification
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic EPO-derived peptide analogue
Molar Weight: 1257.3 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 10 mg

Precautions & Notes

• Experimental behaviour of ARA-290 is influenced by receptor expression, concentration, and model system
• Does not stimulate erythropoiesis in experimental settings
• Buffer composition and pH may affect peptide stability and assay performance
• Appropriate controls are recommended to distinguish receptor-specific from non-specific effects
• Intended strictly for laboratory research use; not for human or veterinary application

References

Brines M., Cerami A. The receptor that tames the innate immune response. Molecular Medicine, 2012.
https://pubmed.ncbi.nlm.nih.gov/22183892/

Brines M. et al. A tissue-protective EPO peptide that does not stimulate erythropoiesis. Proceedings of the National Academy of Sciences, 2008.
https://www.pnas.org/doi/10.1073/pnas.0805594105

Leist M. et al. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science, 2004.
https://pubmed.ncbi.nlm.nih.gov/15247477/

Keywords: ARA-290, Cibinetide, Helix B Surface Peptide, EPO-derived peptide, Innate Repair Receptor, Synthetic Peptide