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Download COA here: FTPP_Adipotide_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

FTPP (Adipotide)

Synonyms / Designations: FTPP, Adipotide, Prohibitin-targeting peptide, Fat-targeting pro-apoptotic peptide
CAS Number: N/A
Molecular Formula: C152H252N44O42
Molecular Weight: 2611.41 g/mol
Peptide Classification: Synthetic chimeric peptide; vascular-targeting peptidomimetic
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 2 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

FTPP (Adipotide) is a synthetic chimeric peptide developed for experimental investigation of adipose tissue vasculature and targeted apoptosis. The molecule combines a prohibitin-binding targeting sequence with a pro-apoptotic peptide domain, enabling selective interaction with endothelial cells associated with adipose tissue in experimental models.

In biochemical and cellular research systems, FTPP has been used to study peptide-mediated targeting, mitochondrial disruption, and programmed cell death pathways. Experimental studies typically focus on receptor binding, intracellular localisation, and downstream apoptotic signalling mechanisms under controlled laboratory conditions. Observed effects are dependent on experimental design, concentration, and model system, and are used to explore vascular and metabolic signalling rather than defined biological or physiological outcomes.

Applications in Research

• Investigation of adipose tissue vascular biology
• Study of peptide-mediated targeting and internalisation
• In vitro and in vivo models examining apoptosis-related signalling
• Use as a research tool in metabolic and vascular biology studies

Handling, Reconstitution & Stability

• Reconstitute in sterile water or appropriate buffered aqueous solution
• Avoid vigorous agitation during dissolution
• Aliquot reconstituted solutions to avoid repeated freeze–thaw cycles
• Store reconstituted material at –20 °C or lower
• Inspect solutions for clarity prior to use

Specifications Summary

Purity: ≥ 99 %
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic chimeric peptidomimetic
Molecular Weight: 2611.41 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 2 mg

Precautions & Notes

• Experimental behaviour of FTPP is highly dependent on targeting efficiency and model system
• Peptide-mediated apoptosis should be evaluated with appropriate controls
• Not all effects observed in animal models translate across systems
• Intended strictly for laboratory research use; not for human or veterinary application

References

Kolonin M.G. et al. Reversal of obesity by targeted ablation of adipose tissue. Nature Medicine, 2004.
https://pubmed.ncbi.nlm.nih.gov/15133506/

Barnhart K.F. et al. Selective targeting of adipose tissue vasculature. Proceedings of the National Academy of Sciences, 2011.
https://pubmed.ncbi.nlm.nih.gov/22072637/

Arap W., Pasqualini R. Peptide targeting of vascular receptors. Cancer Cell, 2012.
https://pubmed.ncbi.nlm.nih.gov/22748625/

Keywords: FTPP, Adipotide, Prohibitin-binding peptide, Adipose targeting peptide, Synthetic chimeric peptide