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Livagen
Synonyms / Designations: Livagen; KEDA; Lys-Glu-Asp-Ala; peptide bioregulator (Khavinson family)
Amino Acid Sequence: Lys-Glu-Asp-Ala (KEDA)
CAS Number: 195875-84-4
Molecular Formula: C18H31N5O9
Molecular Weight: 461.47 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Pack Size: 20 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Livagen (KEDA) is studied in vitro as a chromatin-directed short-peptide probe. In lymphocyte and hepatocyte cultures it has been reported to induce chromatin decondensation (de-heterochromatinisation), activating ribosomal genes and releasing genes repressed by age-related condensation of euchromatic regions, used experimentally to study gene-expression and protein-synthesis programmes in cells from aged donors.
Within the Khavinson model it is a tool for probing chromatin-level transcriptional regulation in immune and hepatic cell systems, including comparative young-versus-old culture studies. Observed effects depend on concentration, model system and exposure conditions.
Applications in Research
- In-vitro lymphocyte chromatin-activation and ribosomal-gene studies
- Hepatocyte gene-expression and protein-synthesis research
- Preclinical models of cellular aging (cell culture and rodent)
- Reference probe for short-peptide transcriptional regulation
Specifications Summary
| Parameter | Typical Value / Range |
|---|---|
| Purity (HPLC) | ≥ 99 % |
| Appearance | White to off-white lyophilised powder |
| Molecular Weight | 461.47 g/mol |
| Peptide Type | Synthetic tetrapeptide bioregulator (Khavinson cytogen family) |
| Solubility | Water, buffered aqueous solutions |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 20 mg (total) |
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic
- Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
- Avoid vigorous agitation during dissolution
- Filter sterilize if required (e.g. 0.22 µm) prior to use
- Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
- Avoid repeated freeze–thaw cycles
Precautions & Notes
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Appropriate experimental controls are recommended
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Khavinson VKh, Lezhava TA, Monaselidze JG, et al. Effects of Livagen Peptide on Chromatin Activation in Lymphocytes from Old People. Bull Exp Biol Med. 2002;134(4):389-392.
https://link.springer.com/article/10.1023/A:1021924702103
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
PubChem Compound Summary, CID 87919683 (Lys-Glu-Asp-Ala).
https://pubchem.ncbi.nlm.nih.gov/compound/87919683
Keywords: Livagen, KEDA, peptide bioregulator, synthetic tetrapeptide, chromatin
