- OP Labs formerly Oxford Peptides
- Batch HPLC tested at ≥ 99% purity
- Storage: –20 °C long term; 2–8 °C short term
- Sold for research purposes only
Cortagen
Synonyms / Designations: Cortagen; AEDP; synthetic short peptide
Amino Acid Sequence: Ala-Glu-Asp-Pro (AEDP)
CAS Number: N/A
Molecular Formula: C17H26N4O9
Molecular Weight: 430.41 g/mol
Purity: ≥ 99% (HPLC)
Appearance: White to off-white lyophilised powder
Pack Size: 20 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Cortagen is a short synthetic tetrapeptide, designed on the basis of amino-acid analysis of a cortical polypeptide preparation, used as a molecular probe for studying tissue-specific gene regulation in nervous-tissue model systems. In experimental settings it is applied to neuronal and glial cultures and to peripheral-nerve models to examine neurotrophic gene expression, cell proliferation and neurite outgrowth.
Cortagen is studied as a candidate cell-penetrating regulator that may bind DNA/histones and modulate promoter activity. It serves as a research tool for probing transcriptional mechanisms in experimental neuroscience preparations; observed effects depend on concentration, model system and exposure conditions.
Applications in Research
- In-vitro neuronal / glial culture gene-expression and neurite-outgrowth assays
- Neuronal cell-stress and oxidative-stress models
- Probe for short-peptide transcriptional regulation in neural tissue
Specifications Summary
| Parameter | Typical Value / Range |
|---|---|
| Purity (HPLC) | ≥ 99% |
| Appearance | White to off-white lyophilised powder |
| Molecular Weight | 430.41 g/mol |
| Peptide Type | Synthetic linear tetrapeptide |
| Solubility | Water, buffered aqueous solutions |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 20 mg (total) |
Precautions & Notes
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Appropriate experimental controls are recommended
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Khavinson VKh, Linkova NS, et al. Short cell-penetrating peptides: a model of interactions with gene promoter sites.
https://pubmed.ncbi.nlm.nih.gov/23484211/
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
Keywords: Cortagen, AEDP, short peptide, synthetic tetrapeptide
