- OP Labs formerly Oxford Peptides
- Batch HPLC tested at 99%+ purity
- Store frozen long term or in fridge when ready to be used
- Sold for research purposes only
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Download COA here: Pancragen_20mg.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.
Pancragen
Synonyms / Designations: Pancragen; KEDW; Lys-Glu-Asp-Trp; pancreatic peptide bioregulator (literature compound is the amidated KEDW-NH2)
Amino Acid Sequence: Lys-Glu-Asp-Trp (KEDW); literature uses the C-terminal amide KEDW-NH2
CAS Number: N/A
Molecular Formula: C26H36N6O9 (free acid); C26H37N7O8 (amide form)
Molecular Weight: 576.25 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Pack Size: 20 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Pancragen (KEDW / KEDW-NH2) is studied in vitro as a pancreas-directed short-peptide probe. In aged human pancreatic cell cultures it has been reported to increase expression of proliferation markers (Ki-67, PCNA) and matrix metalloproteinases, and to alter apoptosis-associated proteins, used experimentally to study acinar/islet differentiation and cell-renewal signalling.
It functions as a molecular tool for probing transcriptional control of pancreatic endocrine/exocrine differentiation and glucose–insulin axis biomarkers in cellular and preclinical models. Observed effects depend on concentration, model system and exposure conditions; no physiological outcome is implied.
Applications in Research
- In-vitro study of pancreatic acinar / islet cell differentiation and proliferation/apoptosis markers
- Preclinical (rodent / aged-primate) models of pancreatic functional decline
- Investigation of peptide effects on glucose–insulin axis biomarkers in experimental systems
- Probe for tissue-specific transcriptional regulation
Specifications Summary
| Parameter | Typical Value / Range |
|---|---|
| Purity (HPLC) | ≥ 99 % |
| Appearance | White to off-white lyophilised powder |
| Molecular Weight | 576.25 g/mol |
| Peptide Type | Synthetic tetrapeptide bioregulator (Khavinson cytogen family; pancreas) |
| Solubility | Water, buffered aqueous solutions |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 20 mg (total) |
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic
- Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
- Avoid vigorous agitation during dissolution
- Filter sterilize if required (e.g. 0.22 µm) prior to use
- Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
- Avoid repeated freeze–thaw cycles
Precautions & Notes
- Confirm whether the supplied material is the free-acid (KEDW) or amidated (KEDW-NH2) form against the batch CoA; molecular weights differ
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Khavinson VKh, et al. Study of biological activity of Lys-Glu-Asp-Trp-NH2 endogenous tetrapeptide. Bull Exp Biol Med. 2010.
https://pubmed.ncbi.nlm.nih.gov/21246099/
Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys. Adv Gerontol.
https://pubmed.ncbi.nlm.nih.gov/25946840/
PubChem Compound Summary, CID 68451868 (H-Lys-Glu-Asp-Trp-NH2).
https://pubchem.ncbi.nlm.nih.gov/compound/68451868
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
Keywords: Pancragen, KEDW, pancreatic peptide bioregulator, synthetic tetrapeptide
