• OP Labs formerly Oxford Peptides
• Batch HPLC tested at 99%+ purity
• Store frozen long term or in fridge when ready to be used
• Sold for research purposes only
• Contact us for Wholesale Orders

Download COA here: Matrixyl_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

Matrixyl (Palmitoyl Pentapeptide-4)

Synonyms / Designations: Matrixyl, Palmitoyl Pentapeptide-4, Palmitoyl-KTTKS, PAL-Lys-Thr-Thr-Lys-Ser, Palmitoyl Pentapeptide-3
CAS Number: 214047-00-4
Molecular Formula: C39H75N7O10
Molar Mass: ~802.05 g/mol
Peptide Classification: Synthetic palmitoylated pentapeptide (matrikine-class research peptide)
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in DMSO; limited solubility in water or dilute aqueous buffers depending on formulation

Description & Mechanism

Matrixyl consists of a short pentapeptide sequence covalently modified at the N-terminus with a palmitoyl fatty acid chain. This lipid conjugation increases hydrophobicity and is used in research settings to study peptide–lipid interactions, peptide stability, and extracellular matrix–associated signalling processes in cellular and formulation-based systems.

In experimental models, Matrixyl is utilised as a reference compound for investigating matrikine-related signalling, peptide uptake dynamics, and the behaviour of lipid-modified peptides in dermal or fibroblast-associated research assays. Observed molecular responses are dependent on experimental design, concentration, formulation matrix, and model system.

Applications in Research

• As a model peptide for studying extracellular matrix–related signalling pathways
• Investigation of lipid-conjugated peptide stability and behaviour in cellular systems
• In vitro studies examining peptide–cell and peptide–matrix interactions
• Reference compound in formulation, compatibility, and peptide delivery research

Handling, Reconstitution & Stability

• Reconstitute shortly before use in DMSO, dilute acid, or suitable buffer depending on assay requirements
• Avoid vigorous agitation during dissolution
• Aliquot reconstituted solutions to minimise repeated freeze–thaw cycles
• Store reconstituted peptide at 4 °C for short-term use; –20 °C or below for long-term storage
• Protect from moisture, strong oxidisers, extreme pH, and elevated temperatures

Specifications Summary

Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Peptide Length: 5 amino acids plus palmitoyl moiety
Molecular Weight: ~802.05 g/mol
CAS: 214047-00-4
Storage: –20 °C, desiccated, dark

Precautions & Notes

• Experimental behaviour of Matrixyl is influenced by formulation matrix, concentration, and model system
• Lipid-modified peptides may exhibit different stability and solubility profiles than non-conjugated peptides
• Buffer composition and solvent choice can significantly affect assay performance
• Intended strictly for laboratory research use; not for human or veterinary application

References

MedKoo Biosciences. Palmitoyl Pentapeptide-4 (Matrixyl®) – technical specifications and CAS data.
https://www.medkoo.com/products/34142

MolNova / TargetMol. Palmitoyl Pentapeptide-4 – molecular formula, molecular weight and peptide sequence information.
https://pubchem.ncbi.nlm.nih.gov/compound/Palmitoyl-Pentapeptide-4

ChemicalBook. Palmitoyl Pentapeptide-4 – physical properties, solubility and handling information.
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB51214034.htm

Croda Beauty (Sederma). Matrixyl® brand information and matrikine peptide background.
https://www.crodabeauty.com/en-gb/resources/technical-library/resource-finder/resource/681-matrixyl-3000

SpecialChem. Palmitoyl Pentapeptide-4 (Matrixyl®) – functional role in cosmetic and dermal research formulations.
https://www.specialchem.com/cosmetics/inci-ingredients/palmitoyl-pentapeptide-4

Kewords: Matrixyl, Matrixyl peptide, Palmitoyl Pentapeptide-4, Palmitoyl KTTKS,. Palmitoylated peptide, Matrikine peptide