• Manufactured to defined purity specifications.
• Store frozen long term or refrigerated when ready to be used.
• Sold for research purposes only.
• Contact us for Wholesale Orders.

Download COA here: MGF_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

MGF (Mechano Growth Factor)

Synonyms / Designations: MGF, Mechano Growth Factor, IGF-1Ec, IGF-1 E-domain peptide, IGF-1 splice variant–derived peptide
CAS Number: 12020-86-9
Molecular Formula: C121H200N42O39
Molecular Weight: 2867.1 g/mol
Peptide Composition: Synthetic peptide corresponding to the E-domain region of the insulin-like growth factor-1 (IGF-1)
Peptide Classification: Synthetic IGF-1 splice-variant–derived peptide
Purity: ≥ 99 % (analytical HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 2 mg
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

MGF (Mechano Growth Factor) is a synthetic peptide derived from the E-domain of the IGF-1 Ec splice variant. It is used in research settings to investigate mechanotransduction-associated signalling, IGF-related peptide processing, and splice-variant–specific peptide behaviour in cellular and molecular models.

In experimental systems, MGF is studied as a distinct molecular entity from full-length IGF-1, with research focusing on peptide stability, receptor interactions, and downstream signalling responses under controlled in vitro conditions. Observed effects are dependent on experimental design, peptide concentration, and model system, and are evaluated for mechanistic insight rather than defined physiological outcomes.

Applications in Research:

• Investigation of IGF-1 splice variant biology and peptide processing
• Studies of mechanotransduction-related signalling pathways
• In vitro research examining peptide–receptor and peptide–matrix interactions
• Use as a reference peptide in growth factor and muscle biology research

Handling, Reconstitution & Stability

• Handle under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution
• Avoid vigorous agitation during dissolution
• Aliquot after reconstitution to minimise degradation
• Store reconstituted solutions at –20 °C or below
• Avoid repeated freeze–thaw cycles

Specifications Summary

Purity: ≥ 99 % (analytical HPLC, typical)
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic IGF-1 splice variant–derived peptide (MGF / IGF-1Ec)
Molecular Weight: 2867.1 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: Commonly supplied as 1 mg or 5 mg

Precautions & Notes

• Experimental behaviour of MGF is influenced by concentration, exposure duration, and experimental model
• As a short peptide derived from an IGF-1 splice variant, MGF may exhibit signalling characteristics distinct
   from full-length IGF-1
• Buffer composition, pH, and enzymatic activity may affect peptide stability
• Peptide fragments may demonstrate rapid degradation in some in vitro systems; appropriate controls are recommended
• Intended strictly for laboratory research use; not for human or veterinary application

References

Goldspink G. Gene expression in muscle in response to exercise. Journal of Muscle Research and Cell Motility, 2003.
https://pubmed.ncbi.nlm.nih.gov/14609023/

Hill M., Goldspink G. Expression and splicing of the IGF-1 gene in muscle during mechanical loading. Journal of Physiology, 2003.
https://pubmed.ncbi.nlm.nih.gov/12692175/

Matheny R.W. et al. Mechano-growth factor regulates skeletal muscle satellite cell activation. American Journal of Physiology – Cell Physiology, 2010.
https://pubmed.ncbi.nlm.nih.gov/20130113/

Keywords: MGF, Mechano Growth Factor, IGF-1 Ec, IGF splice variant peptide, Synthetic research peptide