- OP Labs formerly Oxford Peptides
- Batch HPLC tested at 99%+ purity
- Store frozen long term or in fridge when ready to be used
- Sold for research purposes only
- Contact us for Wholesale Orders
Download COA here: MOTS-C_COA.pdf
Please note: if you have a different Batch ID please contact us for the latest COA.
MOTS-c
Synonyms / Designations: MOTS-c, Mitochondrial ORF of the Twelve S rRNA-c
CAS Number: 1627580-64-6
Molecular Formula: C101H152N28O22S2
Molecular Weight: ~2174.64 g/mol
Peptide Length: 16 amino acids
Peptide Type: Mitochondrial-derived regulatory peptide
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 10 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
MOTS-c is a synthetic peptide corresponding to a naturally occurring mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It is used in experimental research to investigate mitochondrial signalling, metabolic regulation, and nuclear–mitochondrial communication pathways.
In biochemical and cellular research systems, MOTS-c has been shown to influence intracellular signalling pathways associated with energy sensing, insulin signalling, and cellular stress responses. Experimental models examine its effects on AMPK activation, metabolic gene expression, and adaptive stress signalling. Observed molecular responses depend on concentration, exposure duration, and experimental model.
Applications in Research
- As a molecular probe for studying mitochondrial-derived peptide signalling.
- Investigation of metabolic regulation and energy homeostasis pathways.
- In vitro studies examining mitochondrial–nuclear communication.
- Use as a reference compound in metabolism and mitochondrial biology research.
Specifications Summary
Purity (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Molecular Weight: ~2174.64 g/mol
Peptide Type: Mitochondrial-derived peptide
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 10 mg
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic.
- Reconstitute in sterile water or appropriate buffered aqueous solution.
- Avoid vigorous agitation during dissolution.
- Filter sterilize if required prior to use.
- Aliquot and store reconstituted solutions at –20 °C or lower.
- Avoid repeated freeze–thaw cycles.
Precautions & Notes
- Experimental behaviour of MOTS-c is influenced by metabolic state, cell type, and peptide concentration.
- Buffer composition, pH, and ionic strength may affect peptide stability.
- Appropriate controls are recommended.
- Intended strictly for laboratory research use.
References
Lee C. et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 2015.
https://pubmed.ncbi.nlm.nih.gov/25738459/
Reynolds J.C. et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 2021.
https://pubmed.ncbi.nlm.nih.gov/33446706/
Kim K.H. et al. Mitochondrial-derived peptides as novel regulators of metabolism. Journal of Physiology, 2017.
https://pubmed.ncbi.nlm.nih.gov/28488752/
Keywords: MOTS-c, Mitochondrial Peptide, Metabolic Regulation, AMPK Signalling, Synthetic Peptide








Stuart –
Great stuff did exactly what you here that it does for you.
Stuart –
Great stuff did exactly what you here that it does for you.
Stuart –
Great stuff did exactly what you here that it does for you.
Stuart –
Great stuff did exactly what you here that it does for you.
Richard Dolan –
Haven’t used yet so no comment
Chris S. (verified owner) –
Excellent process. Very Easy to order and delivery was next day via royal mail. highly recommended.
Laura (verified owner) –
Anonymous (verified owner) –
Daniel Heavey (verified owner) –
Robert Nightingale (verified owner) –
Good reliable service
Ivan I. (verified owner) –
Joseph Sherrington –
Anonymous –
Robert –
Leighton Adams –
Sara garatly –
Ciaran D. –
Love it
Chris P. –
Great product
James B. –
Great product and fast delivery
Bruce D. –
Jonathan P. –
Great service
Kelly Meyrick –
Great peptide
Migel –
excellent quality and value for money.. i will definitely purchase more in the future ,super fast delivery too..
Alan W. –
Ordered over a week ago and still not arrived. Emailed them twice to say it’s not arrived. Spoken with Royal Mail who say I have to get Oxford labs to report it, which I have done twice with no response as yet. Very disappointed as I have had great service from them previously.
Jarnail singh –
The product is amazing the strength and quality is 100% bang on
Michelle S. –
Love
Clinton W. –
great service ,delivered within a couple of days ,to early to say about quality of products but i`m sure they`ll be no problem from reading other reviews .
Philip B. –
Mots c research going well, appears to be good quality and results
Paul Russell –
Excellent product, very satisfied
Anonymous –
Anonymous –
Excellent product
paul w. –
Simon G. –
I’ve used Oxford Peptides on a number of occasions for different products and been very happy with the quality of each peptide purchased, well priced and quick delivery
Jonny –
Chris S. –
Fast delivery great product
Luke –
Came via next day delivery and without testing vials from experience quality is good.
Elly –
Fast efficient service and great value
Dylan C. –
Sebastian Schreiber –
Jack –
Quick delivery and reasonable price
Joseph Sherrington –
Anonymous –
Robert –
Leighton Adams –
Sara garatly –
Ciaran D. –
Love it
Chris P. –
Great product
James B. –
Great product and fast delivery
Bruce D. –
Jonathan P. –
Great service
Kelly Meyrick –
Great peptide
Migel –
excellent quality and value for money.. i will definitely purchase more in the future ,super fast delivery too..
Alan W. –
Ordered over a week ago and still not arrived. Emailed them twice to say it’s not arrived. Spoken with Royal Mail who say I have to get Oxford labs to report it, which I have done twice with no response as yet. Very disappointed as I have had great service from them previously.
Jarnail singh –
The product is amazing the strength and quality is 100% bang on
Michelle S. –
Love
Clinton W. –
great service ,delivered within a couple of days ,to early to say about quality of products but i`m sure they`ll be no problem from reading other reviews .
Philip B. –
Mots c research going well, appears to be good quality and results
Paul Russell –
Excellent product, very satisfied
Anonymous –
Anonymous –
Excellent product
paul w. –
Simon G. –
I’ve used Oxford Peptides on a number of occasions for different products and been very happy with the quality of each peptide purchased, well priced and quick delivery
Jonny –
Chris S. –
Fast delivery great product
Luke –
Came via next day delivery and without testing vials from experience quality is good.
Elly –
Fast efficient service and great value
Dylan C. –
Sebastian Schreiber –
Jack –
Quick delivery and reasonable price
Joseph Sherrington –
Anonymous –
Robert –
Leighton Adams –
Sara garatly –
Ciaran D. –
Love it
Chris P. –
Great product
James B. –
Great product and fast delivery
Bruce D. –
Jonathan P. –
Great service
Kelly Meyrick –
Great peptide
Migel –
excellent quality and value for money.. i will definitely purchase more in the future ,super fast delivery too..
Alan W. –
Ordered over a week ago and still not arrived. Emailed them twice to say it’s not arrived. Spoken with Royal Mail who say I have to get Oxford labs to report it, which I have done twice with no response as yet. Very disappointed as I have had great service from them previously.
Jarnail singh –
The product is amazing the strength and quality is 100% bang on
Michelle S. –
Love
Clinton W. –
great service ,delivered within a couple of days ,to early to say about quality of products but i`m sure they`ll be no problem from reading other reviews .
Philip B. –
Mots c research going well, appears to be good quality and results
Paul Russell –
Excellent product, very satisfied
Anonymous –
Anonymous –
Excellent product
paul w. –
Simon G. –
I’ve used Oxford Peptides on a number of occasions for different products and been very happy with the quality of each peptide purchased, well priced and quick delivery
Jonny –
Chris S. –
Fast delivery great product
Luke –
Came via next day delivery and without testing vials from experience quality is good.
Elly –
Fast efficient service and great value
Dylan C. –
Sebastian Schreiber –
Jack –
Quick delivery and reasonable price
Joseph Sherrington –
Anonymous –
Robert –
Leighton Adams –
Sara garatly –
Ciaran D. –
Love it
Chris P. –
Great product
James B. –
Great product and fast delivery
Bruce D. –
David C. –
Great service and fast delivery as promised evem during christmas period.
Jonathan P. –
Great service
Kelly Meyrick –
Great peptide
Migel –
excellent quality and value for money.. i will definitely purchase more in the future ,super fast delivery too..
Connor T. –
That’s the shiiiiii
Alan W. –
Ordered over a week ago and still not arrived. Emailed them twice to say it’s not arrived. Spoken with Royal Mail who say I have to get Oxford labs to report it, which I have done twice with no response as yet. Very disappointed as I have had great service from them previously.
Jarnail singh –
The product is amazing the strength and quality is 100% bang on
Michelle S. –
Love
Shaun –
More energy just feel better overall
Clinton W. –
great service ,delivered within a couple of days ,to early to say about quality of products but i`m sure they`ll be no problem from reading other reviews .
Philip B. –
Mots c research going well, appears to be good quality and results
Paul Russell –
Excellent product, very satisfied
Anonymous –
Anonymous –
Excellent product
paul w. –
Simon G. –
I’ve used Oxford Peptides on a number of occasions for different products and been very happy with the quality of each peptide purchased, well priced and quick delivery
Mark France –
Excellent again
Jonny –
Chris S. –
Fast delivery great product
Luke –
Came via next day delivery and without testing vials from experience quality is good.
Elly –
Fast efficient service and great value
Dylan C. –
Sebastian Schreiber –
Jack –
Quick delivery and reasonable price
Rachel Turner wilkinson –
Fantastic product
Matthew McDermott –
Superb service, very fast delivery, as with most peptides, the effects are not acute, so can’t comment on that, but they are certainly sterile.
I have ordered multiple times since my first order, which I think says everything?
Rhiannon Cooper –
Very versatile.
Miss Kavita Gajjar –
Just perfect.
Rachel Turner –
Delivery was super quick, love it.
Tina Appleton –
Fast delivery, works exactly as described.
Wayne Howe –
Product came quicker than expected.
Joe Madren –
Super speedy shipping, product is excellent.
Melanie –
Super quick delivery, very happy.
Megan –
Super quick delivery, love the product.
Nicola B. –
The best product IÕve ever used.
Sarah Fisher –
Super happy with my purchase.
Katie –
Totally worth it.
Lisa Allen –
Works great.
Michelle –
Very impressed with the results.
Stephen –
Great product, great price.
Viki B. –
Great addition to my collection.
Nil Wil –
Delivers as promised.
Audrey Holmes –
No complaints at all.
Anna Pawlowska –
Perfect purchase.
Lauren P. –
Great product, highly recommend.
Rachel Rendle –
Highly reliable.
Zoe –
IÕm super satisfied.
Sophie Palmer –
Fast delivery.
Toni –
Just amazing.
Melinda –
Extremely satisfied.
Julia F. –
Highly satisfied.
Fiona W. –
Best decision ever.
Elizabeth –
Very reliable.
Danielle H. –
Loving it so far.
susan c. –
ItÕs a lifesaver.
Lisa Hoey –
ItÕs perfect.
Sharon M. –
CouldnÕt be happier.
Michelle Cooke –
The best product IÕve ever used.
Kirsten Hendry –
Performs better than I thought.
Rebecca Barnes –
Awesome purchase.
Joanne Brettle –
A total game-changer.
Lewis Bensted –
CouldnÕt be better.
Anonymous –
Great design and quality.
Ashley Berrisford –
Worth every penny.
Stacey G. –
Delivered quickly, very satisfied.
Aimee R. –
Arrived so fast, couldnÕt believe it.
Natalia –
So happy with the fast delivery!
Adrian P. –
Beyond impressed.
Oliver Anthony –
Excellent quality.
Anonymous –
The best IÕve seen.
Dawn –
ItÕs perfect for me.
Jamie –
Thrilled with this purchase.
Helen Robinson –
This is a game-changer.
Arthur Caulfield –
Very happy with the quality.
Hannah Horan –
IÕm blown away by the quality.
Sarah D. –
A must-buy.
Kay Hunt –
Excellent choice.
Charlotte –
A great buy.
Sam –
Super happy with my purchase.
Venetia –
ItÕs awesome.
Paula Kenrick –
ItÕs perfect for me.
Paula P. –
Incredibly useful.
Gemma –
Great design and quality.
Khilna –
IÕm obsessed.
Darrell Roberts –
Arrived fast, amazing product.
Alice B. –
Arrived so fast, couldnÕt believe it.
Stefanie Camborne-Paynter –
Fast delivery and perfect product.
Rhoslyn –
Totally satisfied with this.
Karen Yvonne Hills –
So glad I found this.
Laura –
Love the results.
Claudia Gozzi –
Super useful.
Paul R. –
Well worth it.
Bailey –
Highly recommend.
Susan Gardler –
This is an incredible buy.
Sophie –
Performs wonderfully.
Mike Eve –
Totally dependable.
Paul –
ItÕs awesome.
Emma –
CouldnÕt be happier.
Emma A. –
Awesome quality.
abigail –
Worth every penny.
Janet –
Arrived fast, no complaints at all.
Charlotte –
Delivered fast, love the product!
Caron Butler –
Product arrived quickly, just as described.
Anonymous –
Very fast delivery, love the product.
Rachel –
Delivery was fast and hassle-free.
Lara H. –
Got here faster than anticipated.
Ellen Richardson –
Got it fast, very pleased with the quality.
Paolo –
Fast delivery and excellent product.
Rachael Anderson –
Fast delivery, very impressed.
Samantha B. –
Performs better than I thought.
Emily M. –
Extremely happy with my choice.
Kyle D. –
ItÕs really top-notch.
Melinda –
Very high-end.
Sarah Taylor –
Absolutely love using it.
Perry Farman –
Love how it performs.
Samantha K. –
Amazing quality.
Harley –
CanÕt recommend enough.
Sandor Elteto –
I love this thing.
Dan Twine –
A real gem.
Anonymous –
Five stars.
Sarah –
Great value.
Delme –
ItÕs a perfect fit.
Seema D. –
A must-buy.
Steven –
So pleased with this.
Tony Dove –
Super helpful.
Autumn K. –
Happy customer.
Anonymous –
Excellent quality product.
Ashton Leung –
So glad I found this.
David –
Super happy I found this.
Anonymous –
Fast delivery and high quality.
Memphis –
So pleased with this.
Gemma V. –
Worth every penny..
Anonymous –
Delivery was fast and hassle-free.
Raakhi Kadambi –
Impressed by the fast delivery!
Lisa A. –
Great purchase.
Christine Blake –
IÕm really pleased with this.
Paula –
A great product.
Anonymous –
Fast delivery, exceeded my expectations.
Natalie –
Fast delivery and works great.
Heather –
Amazing craftsmanship.
Kim –
Very disappointed with the performance.
Jessica Henderson –
Had to wait ages for this.
Elaine Budd –
Took much longer than expected to arrive.
Mark T. –
Waited way too long for this.
Tim D. –
Was expecting faster delivery, very disappointed.
Saara Hanso –
Took way too long to arrive.
Klaudia –
Definitely wouldnÕt recommend.
Anonymous –
Not impressed with the shipping speed.
Anonymous –
Took much longer than expected to arrive.
Anonymous –
Extremely slow shipping.
Cheraldine W. –
Shipping took way too long.
John Chambers –
Competitive price,good quality too
Paul Russell –
Great product .very effective
Paul Russell –
Great product .very effective
Paul Russell –
Great product .very effective
Paul Russell –
Great product .very effective
audrius leliuga –
Good
Steven Jones –
Steven Jones –
Steven Jones –
Steven Jones –
James H. –
James H. –
James H. –
James H. –
Gerhardus Engelbrecht –
Fast delivery & great quality peptides – have ordered a few times very happy with product
Sean M. –
Arrived quickly and can feel a difference in energy levels already
Sean M. –
Arrived quickly and can feel a difference in energy levels already
Sean M. –
Arrived quickly and can feel a difference in energy levels already
Sean M. –
Arrived quickly and can feel a difference in energy levels already
Anonymous –
Great for research
Anonymous –
Great for research
Anonymous –
Great for research
Anonymous –
Great for research
Richard Meynell –
Still waiting for delivery
Richard Meynell –
Still waiting for delivery
Richard Meynell –
Still waiting for delivery
Richard Meynell –
Still waiting for delivery
david john THOMAS –
david john THOMAS –
david john THOMAS –
david john THOMAS –
Paul Stephenson –
Awesome
Paul Stephenson –
Awesome
Paul Stephenson –
Awesome
Paul Stephenson –
Awesome
Duane –
It was easy to use and no adverse effects. It seems to be having a good effect but more time is needed on this to verify its efficacy.
Anonymous –
Anonymous –
Anonymous –
Anonymous –
Gary T. –
Excellent
Ryan C. –
Ordered a few times from Oxford peptides, never had any issues, good customer service and fast delivery. All the products used work well.
Jarnail Singh –
Jarnail Singh –
Jarnail Singh –
Jarnail Singh –
Anonymous –
Came fast as always and is a high quality product, again. Oxford peptides is consistent and reliable.
Anonymous –
Came fast as always and is a high quality product, again. Oxford peptides is consistent and reliable.
Anonymous –
Came fast as always and is a high quality product, again. Oxford peptides is consistent and reliable.
Anonymous –
Came fast as always and is a high quality product, again. Oxford peptides is consistent and reliable.
Anonymous –
Not been having it long enough yet to coment
Kevin C. –
Kevin C. –
Kevin C. –
Kevin C. –
Russell –
Russell –
Russell –
Russell –
Russell H. –
Perfect quality
Russell H. –
Perfect quality
Russell H. –
Perfect quality
Russell H. –
Perfect quality
richard b. –
This stuff is real from the first day I used it I felt the energy. It’s very strong
richard b. –
This stuff is real from the first day I used it I felt the energy. It’s very strong
richard b. –
This stuff is real from the first day I used it I felt the energy. It’s very strong
richard b. –
This stuff is real from the first day I used it I felt the energy. It’s very strong
Stephen Hill –
Great product, great service….used OP before and never disappointed. First time using MotsC in my peptide stack so I can update with results
Emily Kew –
Beyond my expectations.
Anastacia –
Great purchase.
susan craker –
No complaints at all.
Suzie Irving –
Exceeded my expectations.
Gemma Haworth –
High-quality product.
Victoria –
Very versatile.
Ben C. –
CouldnÕt be better.
Gemma-Lee –
Well worth it.
Maria D. –
Speedy delivery, couldnÕt be happier.
Cilia –
Waited way too long for this.
Angelina Perrett –
Delivered much faster than expected.
Kayleigh –
Arrived so fast, couldnÕt believe it.
Talia –
Ridiculously slow delivery.
Georgie Kelly –
Got here faster than anticipated.
Sydney King –
Fast shipping, just as described.
Joanne N. –
Delivered fast, love the product!
Naomi P. –
Super fast delivery, no issues at all.
Emma Mendes da Costa –
Speedy delivery, couldnÕt be happier.
Anna C. –
Fast delivery and works perfectly.
Tia B. –
Fast delivery and excellent product.
Jackie O. –
CanÕt live without it now.
Verified Buyer –
Very happy with the quality.
Rosie Kelly –
Best quality IÕve had.
Verified Buyer –
Love this purchase.
Mick –
Awesome purchase.
Verified Buyer –
Does the trick.
Edmund N. –
Truly amazing.
Verified Buyer –
Best thing IÕve bought.
Barb Clifford –
Lives up to the hype.
Rhonagh –
CanÕt stop using it.
tess w. –
CouldnÕt be better.
Fiona Thomas –
So glad I bought it.
Richard H. –
Love everything about it.
Debbie Edwards –
Super quick delivery, very happy.
Naemi Kumar –
Delivery was fast and hassle-free.
Holly Ward –
Product came quicker than expected.
Georgia Danes –
Great product and fast shipping.
Laura –
Was expecting faster delivery, very disappointed.
Esme P. –
Extremely happy with this.
Sallyann W. –
CouldnÕt be more satisfied.
Will Johnson –
Product is fine, but the delivery was a joke.
Nicola M. –
IÕm totally impressed.
Kristine –
Absolutely love using it.
Fanni F. –
Why did this take forever to arrive?
Alexandra B. –
Delivery was super quick, love it.
Claire K. –
Super quick delivery, very happy.
Jo-Ann –
Delivered much faster than expected.
Richard Mawer –
Very fast delivery, love the product.
Dulcie R. –
Product arrived fast, love it.
Matthew –
Delivery was much slower than expected.
Clare M. –
Disappointed with how long it took to get here.
Troy Miles –
Happy customer.
Monique –
Super happy with how it works.
Ben –
Truly amazing.
Antonia A. –
I love this thing.
Jade F. –
High quality.
Sam Morris –
No complaints at all.
Hannah Veasey –
Excellent performance.
Jarrad Harries –
Love everything about it.
Katie R. –
Absolutely love this.
Lisa –
Happy customer.
Lee Cooper –
Very reliable.
Frances –
CanÕt live without it.
Rebecca A. –
Totally satisfied with this.
Emily P. –
Fantastic performance.
Jessica B. –
ItÕs a perfect fit.
Ciara Beckett –
A must-buy.
Suzanne Cruwys –
Great quality product.
Anonymous –
Very pleased with this.
Sophie Harris –
Top-notch quality.
Sarah C. –
Best purchase ever.
Julie –
CouldnÕt be happier.
Ian Bridle –
Just what I was looking for.
Fraser –
Absolutely love the quality.
Emily –
Simply amazing.
Michelle Dunstan –
This is amazing quality.
Hannah –
Amazing quality.
Vince Chiappinelli –
ItÕs just fantastic.
Mark –
High-quality product.
Rebecca Lacey –
Super helpful.
Neil Marshall –
Amazed by the quick delivery.
Jade Thompson –
Great quality product.