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• Batch HPLC tested at 99%+ purity
• Store frozen long term or in fridge when ready to be used
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Download COA here: Thymalin_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

Thymalin

Synonyms / Designations: Thymalin, Thymus Peptide Complex, Thymic Peptide Preparation
CAS Number: 63958-90-7
Molecular Formula: C33H54N12O15
Molecular Weight: 858.86 g/mol
Peptide Composition: Mixture of short thymic peptides (predominantly 2–10 amino acids)
Peptide Classification: Synthetic thymus-derived peptide complex
Purity: 99 % (HPLC, typical; total peptide content)
Appearance: White to off-white lyophilised powder
Pack Size: 10 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

Thymalin is a low-molecular-weight thymic peptide preparation developed for experimental investigation of thymus-derived signalling pathways involved in cellular differentiation, gene regulation, and immune-associated cellular processes. It represents a defined peptide fraction originally characterised from thymic tissue and subsequently produced in synthetic form for research applications.

In biochemical and cellular research systems, thymalin-derived peptides are studied for their influence on gene expression, chromatin-associated regulation, and cell-cycle–related signalling pathways, particularly in immune and progenitor cell models. Experimental studies typically explore transcriptional modulation, peptide–DNA interactions, and regulatory effects on cellular differentiation under controlled laboratory conditions. Observed molecular responses depend on peptide composition, concentration, exposure duration, and experimental model and are used to investigate regulatory signalling mechanisms rather than defined biological or physiological outcomes.

Applications in Research

• Investigation of thymus-derived peptide signalling and gene regulation
• In vitro studies of cellular differentiation and immune-associated signalling pathways
• Experimental models examining chromatin activity and transcriptional modulation
• Use as a reference preparation in thymic peptide and immunoregulatory research

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide preparation may be hygroscopic.
• Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements.
• Avoid vigorous agitation during dissolution.
• Filter sterilize if required immediately prior to use. Aliquot and store reconstituted solutions at –20 °C (or lower).
• Avoid repeated freeze–thaw cycles.

Specifications Summary

Purity: > 99 %
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic thymus-derived peptide complex
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 10 mg

Precautions & Notes

• Experimental behaviour is influenced by peptide composition, concentration, and experimental model.
• Peptide complexes may exhibit signalling profiles distinct from individual isolated peptides.
• Buffer composition, pH, and ionic strength may affect stability and assay performance.
• Appropriate controls are recommended. Intended strictly for laboratory research use only; not for human or veterinary application.

References

Khavinson V.K. et al. Peptides and ageing. Neuroendocrinology Letters, 2002.
https://pubmed.ncbi.nlm.nih.gov/12374906/

Morozov V.G., Khavinson V.K. Natural and synthetic thymic peptides as therapeutics for immune dysfunction. International Journal of Immunopharmacology, 1997.
https://pubmed.ncbi.nlm.nih.gov/9386961/

Khlystova Z.S. et al. Thymalin: structure, properties and clinical application. Bulletin of Experimental Biology and Medicine, 2003.
https://pubmed.ncbi.nlm.nih.gov/14614509/

Keywords: Thymalin, Thymic Peptides, Thymus-Derived Peptide Complex, Synthetic Peptides, Gene Regulation, Immunoregulatory Signalling, Research Peptide