Representative specimen data. These are typical results for this product. Actual results are batch-specific and are printed on the certificate for the batch number on your vial. Research use only.
| Parameter | Result |
|---|---|
| Product name | Semax |
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.92 g/mol |
| Appearance | White to off-white powder |
| Test method | RP-HPLC (C18), UV detection at 220 nm |
| Purity (HPLC) | 98.97% (specification ≥ 98.5%) |
| Mass-spec identity | ESI-MS (positive): [M+H]+ 814.9, confirming 813.92 g/mol |
| Water content | 6.9% (Karl Fischer, specification ≤ 10.0%) |
| Analysis date | Representative specimen — the analysis date is printed on each batch certificate |
- OP Labs formerly Oxford Peptides
- Batch HPLC tested at 98.5%+ purity
- Store frozen long term or in fridge when ready to be used
- Sold for research purposes only
- Contact us for Wholesale Orders
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Semax
Synonyms / Designations: Semax, ACTH(4–7) Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro
CAS Number: 80714-61-0
Molecular Formula: C37H51N9O10S
Molecular Weight: ~813.92 g/mol
Peptide Length: 7 amino acids
Peptide Type: Synthetic neuropeptide (ACTH(4–7) analogue)
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone fragment ACTH(4–7), modified with a C-terminal Pro–Gly–Pro sequence to enhance metabolic stability. It was developed for experimental investigation of neuropeptide signalling, neuromodulation, and central nervous system regulatory pathways.
In biochemical and cellular research systems, Semax has been studied for its interactions with neuronal signalling pathways associated with neurotrophic factors, synaptic plasticity, and stress-response regulation. Experimental models commonly investigate its effects on intracellular signalling cascades, gene expression related to neurotrophins, and modulation of neurotransmitter systems. Observed molecular responses are dependent on experimental design, concentration, and model system.
Applications in Research
- As a molecular probe for studying neuropeptide-mediated signalling pathways.
- Investigation of neuronal plasticity, neurotrophic signalling, and stress-related molecular mechanisms.
- In vitro and in vivo research examining peptide stability and CNS-active peptide analogues.
- Use as a reference compound in neurobiology and peptide signalling research.
Specifications Summary
Purity (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Molecular Weight: ~813.92 g/mol
Peptide Type: Synthetic ACTH-derived neuropeptide
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic.
- Reconstitute in sterile water or appropriate buffered aqueous solution.
- Avoid vigorous agitation during dissolution.
- Filter sterilize if required (e.g. 0.22 µm) prior to use.
- Aliquot and store reconstituted solutions at –20 °C or lower.
- Avoid repeated freeze–thaw cycles.
Precautions & Notes
- Experimental behaviour of Semax is influenced by neuronal model, receptor expression, peptide concentration, and exposure duration.
- Buffer composition, pH, and ionic strength may affect peptide stability.
- Appropriate controls are recommended to distinguish specific from non-specific effects.
- Intended strictly for laboratory research use; not for human or veterinary application.
References
Ashmarin I.P. et al. Semax as a regulator of neurotrophic factors. Neuroscience and Behavioral Physiology, 1997.
https://pubmed.ncbi.nlm.nih.gov/9404683/
Gusev E.I. et al. Neuropeptide Semax in experimental models of brain function. Neuroscience and Behavioral Physiology, 2000.
https://pubmed.ncbi.nlm.nih.gov/10739407/
Myasoedov N.F. et al. ACTH-derived peptides and central nervous system regulation. Journal of Peptide Science, 2011.
https://pubmed.ncbi.nlm.nih.gov/21491577/
Keywords: Semax, ACTH(4–7), Synthetic Neuropeptide, CNS Signalling, Neurotrophic Peptide
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Fantastic product. Even after a short time I feel a huge difference in mood and cognitive function.
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Conner Crotchett –
Joanna –
Works wonders I am keep reordering this . Great
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Easy to order and delivered next day. Will definitely be ordering again.
Elo –
Elo –
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Aaron (Verified Purchase) –
Item as expected, test subject is responding well to the research peptides. Great product as always
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Jared (Verified Purchase) –
Good quality
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Aldis A. (Verified Purchase) –
Good services and quality products. Thank you with respect Aldis.
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Fast deliver, reasonable price and good product
Anonymous –
Kenneth Dilliway –
Josh –
Another wasted peptide
clickanddrop –
If there are issues with the order just let us know and we will try to resolve. Most people don’t agree with you 🙂
Fred E. –
Never received
clickanddrop –
If there are issues with the order just let us know and we will try to resolve.
Shaun –
Excellent thanks
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The effects are fairly weak may be placebo but it helps with concentration
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Excellent
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Fast deliver, reasonable price and good product
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Love this, helps with ADHD, learning and focus. Take early in the day for long lasting benefits later in the day.
Kenneth Dilliway –
Anonymous –
Great service, quick delivery and great quality.
Thanks
Josh –
Another wasted peptide
Michelle S. –
Brilliant product
Fred E. –
Never received
Shaun –
Excellent thanks
Anonymous –
The effects are fairly weak may be placebo but it helps with concentration
Anonymous –
Excellent
Anonymous –
Anonymous –
Anonymous –
Been using this for a brain injury and has really helped me feel like myself again. This along side with fasting and a correct diet is healing me
Justin –
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Samer –
Very fast delivery very professional approach towards customers would recommend and will buy again.
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Superb service, very fast delivery, this does have some noticeable effects on my ADHD research subjects, it’s early days, but promising so far.
I have ordered multiple times since my first order, which I think says everything?
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So glad I bought it.
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Performs better than I thought.
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Highly satisfied.
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Five stars.
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A must-have.
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Works incredibly well.
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Very practical.
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Quality is amazing.
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Love this purchase.
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Well made.
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Perfect purchase.
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A must-buy.
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Dennis B. –
Not worth the wait.
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It took forever to get here.
David Moir –
Works best first thing. Combined with Selank works wonders.
David Moir –
Works best first thing. Combined with Selank works wonders.
Aiden R. –
Didn’t really notice a difference in cognitive function however didn’t pair with Selmax and don’t normally respond well with compounds that change mental function
Aiden R. –
Didn’t really notice a difference in cognitive function however didn’t pair with Selmax and don’t normally respond well with compounds that change mental function
Bruno –
Bruno –
Russell –
Russell –
Anonymous –
Great product, on my reorder list and always with the same seller
Krystian K. –
Krystian K. –
Scott –
Product is good quality customer service isn’t great
Scott –
Product is good quality customer service isn’t great
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Love this item.
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Totally worth the price.
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Excellent value for money.
Cilia –
Why did it take so long to ship?
Kelly Harvey –
Definitely not what I was hoping for.
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Fast delivery, very satisfied with my purchase.
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Delivery was super fast and seamless.
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Product came quicker than expected.
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This is an incredible buy.
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Product arrived quickly, just as described.
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