Representative specimen data. These are typical results for this product. Actual results are batch-specific and are printed on the certificate for the batch number on your vial. Research use only.
| Parameter | Result |
|---|---|
| Product name | Tesamorelin |
| CAS number | 901758-09-6 |
| Molecular formula | C221H366N72O67S |
| Molecular weight | 5135.91 g/mol |
| Appearance | White to off-white powder |
| Test method | RP-HPLC (C18), UV detection at 220 nm |
| Purity (HPLC) | 98.57% (specification ≥ 98.5%) |
| Mass-spec identity | ESI-MS (positive): [M+4H]4+ 1285.0, confirming 5135.91 g/mol |
| Water content | 3.1% (Karl Fischer, specification ≤ 10.0%) |
| Analysis date | Representative specimen — the analysis date is printed on each batch certificate |
- OP Labs formerly Oxford Peptides.
- Batch HPLC tested at 98.5%+ purity.
- Store frozen long term or in fridge when ready to be used.
- Sold for research purposes only.
- Contact us for Wholesale Orders.
Search our database for full COA analytics here.
Tesamorelin
Synonyms / Designations: Tesamorelin, TH9507, Growth Hormone–Releasing Hormone (GHRH) analogue
CAS Number: 901758-09-6
Molecular Formula: C223H370N72O69S
Molecular Weight: ~5135.91 g/mol
Peptide Length: 44 amino acids
Peptide Type: Synthetic GHRH analogue
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Tesamorelin is a synthetic peptide analogue of human growth hormone–releasing hormone (GHRH 1–44) designed for experimental investigation of hypothalamic–pituitary signalling and growth hormone regulation. Structural modifications enhance stability relative to native GHRH, making Tesamorelin suitable for controlled laboratory research.
In biochemical and cellular research systems, Tesamorelin interacts with the GHRH receptor expressed on pituitary-derived cells, activating intracellular signalling cascades associated with growth hormone synthesis and secretion. Experimental studies examine receptor binding kinetics, cAMP-mediated signalling, and downstream transcriptional responses under defined exposure conditions. Observed effects are dependent on concentration, duration, and experimental model and are used to investigate GHRH receptor signalling rather than defined physiological outcomes.
Applications in Research
- As a molecular probe for studying GHRH receptor activation and signalling pathways.
- Investigation of growth hormone regulatory mechanisms in pituitary cell models.
- In vitro studies examining peptide stability and receptor selectivity.
- Use as a reference compound in neuroendocrine and peptide signalling research.
Specifications Summary
Purity: (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Molecular Weight: ~5135.91 g/mol
Peptide Type: Synthetic GHRH analogue
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic.
- Reconstitute in sterile water or appropriate buffered aqueous solution.
- Avoid vigorous agitation during dissolution.
- Filter sterilize if required (e.g. 0.22 µm) prior to use.
- Aliquot and store reconstituted solutions at –20 °C or lower.
- Avoid repeated freeze–thaw cycles.
Precautions & Notes
- Experimental behaviour of Tesamorelin is influenced by receptor expression, peptide concentration, and exposure duration.
- Buffer composition, pH, and ionic strength may affect peptide stability.
- Appropriate controls are recommended to distinguish receptor-specific from non-specific effects.
- Intended strictly for laboratory research use; not for human or veterinary application.
References
Thorner M.O. et al. Growth hormone–releasing hormone and its analogues. Endocrine Reviews, 1997.
https://pubmed.ncbi.nlm.nih.gov/9107404/
Bowers C.Y. Growth hormone–releasing peptides and neuroendocrine regulation. Endocrine Reviews, 2001.
https://pubmed.ncbi.nlm.nih.gov/11159057/
Vance M.L. Growth hormone releasing hormone and pituitary signalling. Journal of Clinical Endocrinology & Metabolism, 2003.
https://pubmed.ncbi.nlm.nih.gov/12629096/
Keywords: Tesamorelin, TH9507, GHRH Analogue, Growth Hormone Regulation, Synthetic Peptide
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