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DSIP

Synonyms / Designations: DSIP, Delta Sleep–Inducing Peptide, Delta sleep peptide
CAS Number: 62568-57-4
Molecular Formula: C₃₅H₄₈N₁₀O₁₅
Molecular Weight:~848.82 g/mol
Peptide Classification: Naturally occurring nonapeptide; classified as a neuropeptide in experimental models
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in water, dilute acetic acid, and phosphate-buffered saline (PBS)

Description & Mechanism

Delta Sleep–Inducing Peptide (DSIP) is a naturally occurring nonapeptide first identified in studies of neurochemical signalling associated with sleep-related brain activity. It has been detected in central nervous system tissues, peripheral organs, and various biological fluids across multiple animal models, although its biosynthetic origin and precursor structure remain incompletely characterised.

In biochemical and cellular research systems, DSIP has been examined for its involvement in neuroendocrine signalling, stress-associated pathways, and peptide–receptor interactions. Experimental studies suggest that DSIP may interact with multiple signalling mechanisms, including NMDA receptor–related pathways and MAPK-associated signalling cascades, with observed effects dependent on concentration, exposure duration, and experimental context. DSIP is primarily utilised as a molecular tool to investigate neuropeptide signalling rather than defined physiological outcomes.

Applications in Research

• As a molecular probe for studying neuropeptide-mediated signalling in central nervous system models
• Investigation of peptide interactions within neuroendocrine and stress-related pathways
• In vitro studies examining peptide stability, degradation, and carrier-protein interactions
• As a reference compound in research involving short endogenous neuropeptides

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water, dilute acetic acid, or appropriate buffered aqueous solution depending on assay requirements
• Avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradation
• Avoid repeated freeze–thaw cycles
• Due to reported low intrinsic stability in vitro, prepare fresh working solutions when possible

Specifications Summary

Precautions & Notes

• Experimental behaviour of DSIP is dependent on concentration, exposure duration, and model system
• Buffer composition, pH, and enzymatic activity may influence peptide stability
• Due to reported rapid degradation in some in vitro systems, appropriate controls are recommended
• Literature reports describe heterogeneous and sometimes contradictory findings across models
• Intended strictly for laboratory research use; not for human or veterinary application

References

Schneider-Helmert D., Schoenenberger G.A. Effects of DSIP in man. Multifunctional effects of a neuropeptide. Neuropsychobiology, 1983.
https://pubmed.ncbi.nlm.nih.gov/1299794/

Kovalzon V.M., Strekalova T.V. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of Neurochemistry, 2006.
https://pubmed.ncbi.nlm.nih.gov/16539679/

Bocheva A. et al. DSIP and its analogues: potential neuroprotective research applications. Molecules, 2021.
https://www.mdpi.com/1420-3049/26/17/5173

Keywords: DSIP, Delta Sleep–Inducing Peptide, Synthetic Nonapeptide