- OP Labs formerly Oxford Peptides
- Batch HPLC tested at ≥ 99% purity
- Storage: –20 °C long term; 2–8 °C short term
- Sold for research purposes only
Livagen
Synonyms / Designations: Livagen; KEDA; Lys-Glu-Asp-Ala; synthetic short peptide
Amino Acid Sequence: Lys-Glu-Asp-Ala (KEDA)
CAS Number: 195875-84-4
Molecular Formula: C18H31N5O9
Molecular Weight: 461.47 g/mol
Purity: ≥ 99% (HPLC)
Appearance: White to off-white lyophilised powder
Pack Size: 20 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Livagen (KEDA) is studied in vitro as a chromatin-directed short-peptide probe. In lymphocyte and hepatocyte cultures it has been reported to induce chromatin decondensation (de-heterochromatinisation), activating ribosomal genes and releasing genes repressed by condensation of euchromatic regions, used experimentally to study gene-expression and protein-synthesis programmes in cultured cells.
It is a tool for probing chromatin-level transcriptional regulation in immune and hepatic cell systems. Observed effects depend on concentration, model system and exposure conditions.
Applications in Research
- In-vitro lymphocyte chromatin-activation and ribosomal-gene studies
- Hepatocyte gene-expression and protein-synthesis research
- Reference probe for short-peptide transcriptional regulation
Specifications Summary
| Parameter | Typical Value / Range |
|---|---|
| Purity (HPLC) | ≥ 99% |
| Appearance | White to off-white lyophilised powder |
| Molecular Weight | 461.47 g/mol |
| Peptide Type | Synthetic tetrapeptide |
| Solubility | Water, buffered aqueous solutions |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 20 mg (total) |
Precautions & Notes
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Appropriate experimental controls are recommended
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
PubChem Compound Summary, CID 87919683 (Lys-Glu-Asp-Ala).
https://pubchem.ncbi.nlm.nih.gov/compound/87919683
Keywords: Livagen, KEDA, short peptide, synthetic tetrapeptide, chromatin
