- OP Labs formerly Oxford Peptides
- Batch HPLC tested at 99%+ purity
- Store frozen long term or in fridge when ready to be used
- Sold for research purposes only
- Contact us for Wholesale Orders
Download COA here: N-Acetyl-Epitalon_10mg.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.
N-Acetyl Epitalon
Synonyms / Designations: N-Acetyl Epitalon; N-Acetyl Epithalon; Ac-Epitalon; N-acetylated AEDG (Ac-Ala-Glu-Asp-Gly-OH)
Amino Acid Sequence: Ac-Ala-Glu-Asp-Gly-OH (N-terminally acetylated AEDG tetrapeptide)
CAS Number: N/A
Molecular Formula: C14H22N4O9
Molecular Weight: 390.4 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Pack Size: 10 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
N-Acetyl Epitalon is an N-terminally acetylated analogue of the synthetic tetrapeptide Epitalon (AEDG), used as a research reagent to study the parent peptide’s reported activities in experimental systems. In cell and tissue models, Epitalon-family peptides have been studied as putative modulators of telomerase (TERT) expression and as short peptides proposed to interact with DNA/chromatin to influence gene-expression patterns.
N-terminal acetylation is a common chemical modification intended to reduce aminopeptidase cleavage and improve in-vitro stability and handling relative to the unmodified peptide. As a laboratory probe the molecule is used to interrogate proposed peptide–gene-regulation effects, antioxidant/cytoprotective endpoints and senescence-related markers in cell culture; described effects are mechanistic and in-vitro in nature.
Applications in Research
- In-vitro studies of telomerase (TERT) expression and replicative senescence in cultured cells
- Cellular models probing short-peptide modulation of gene expression / chromatin interaction
- Antioxidant and cytoprotective endpoint assays in cell culture
- Comparative stability studies of acetylated vs native tetrapeptides (peptide chemistry research)
Specifications Summary
| Parameter | Typical Value / Range |
|---|---|
| Purity (HPLC) | ≥ 99 % |
| Appearance | White to off-white lyophilised powder |
| Molecular Weight | 390.4 g/mol |
| Peptide Type | Synthetic acetylated tetrapeptide (Epitalon-family pineal peptide analogue) |
| Solubility | Water, buffered aqueous solutions |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 10 mg (total) |
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic
- Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
- Avoid vigorous agitation during dissolution
- Filter sterilize if required (e.g. 0.22 µm) prior to use
- Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
- Avoid repeated freeze–thaw cycles
Precautions & Notes
- Confirm the exact entity supplied (free-acid Ac-AEDG-OH vs amidated Ac-AEDG-NH2) against the batch CoA; molecular weights differ
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
NCATS Inxight Drugs — N-Acetyl Epitalon (UNII UXR7AF6R4F).
https://drugs.ncats.io/substance/UXR7AF6R4F
PubChem Compound Summary, CID 171390141 (N-Acetyl Epitalon).
https://pubchem.ncbi.nlm.nih.gov/compound/171390141
Overview of Epitalon — a pineal tetrapeptide with reported bioactivity (review). PMC11943447.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943447/
Keywords: N-Acetyl Epitalon, N-Acetyl Epithalon, acetylated AEDG, synthetic tetrapeptide
