- OP Labs formerly Oxford Peptides.
- Batch HPLC tested at 99%+ purity.
- Store frozen long term or in fridge when ready to be used.
- Sold for research purposes only.
- Contact us for Wholesale Orders.
Download COA here: PE-22-28_COA.pdf
Please note: if you have a different Batch ID please contact us for the latest COA.
PE-22-28
Synonyms / Designations: PE-22-28, Pancreatic Polypeptide (22–28) fragment, PP(22–28), C-terminal pancreatic polypeptide fragment
CAS Number: 1801959-12-5
Molecular Formula: C35H56N12O9
Molecular Weight: ~773.89 g/mol
Peptide Sequence: Arg–Pro–Tyr–Leu–Gly–Pro–Arg
Peptide Classification: Synthetic peptide fragment derived from pancreatic polypeptide (PP)
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
PE-22-28 is a synthetic peptide corresponding to amino acids 22–28 of pancreatic polypeptide (PP), an endogenous peptide hormone involved in neuroendocrine signalling. The fragment represents a structurally defined region commonly used in research to study sequence-specific peptide–receptor interactions independent of the full-length parent molecule.
In biochemical and cellular research systems, PE-22-28 has been investigated for its interaction with Y-family peptide receptors and its role in modulating peptide signalling pathways associated with pancreatic and neuroendocrine communication. Experimental observations are dependent on model system, receptor expression, concentration, and exposure duration, and are used to explore signalling mechanisms rather than defined physiological outcomes.
Applications in Research
- As a molecular probe for studying pancreatic polypeptide–derived signalling
- Investigation of Y-receptor binding and peptide–receptor interaction dynamics
- In vitro studies examining structure–function relationships of PP fragments
- Use as a reference compound in neuroendocrine and peptide signalling research
Specifications Summary
Purity: ≥ 99 %
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic pancreatic polypeptide fragment
Molecular Weight: ~773.89 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg
Precautions & Notes
- Experimental behaviour of PE-22-28 is influenced by receptor expression and assay conditions
- Peptide fragments may exhibit signalling profiles distinct from full-length pancreatic polypeptide
- Buffer composition, pH, and ionic strength may affect peptide stability
- Appropriate experimental controls are recommended
- Intended strictly for laboratory research use; not for human or veterinary application
References
Chance W.T. et al. Pancreatic polypeptide and its fragments: receptor interactions and biological activity. Peptides, 1995.
https://pubmed.ncbi.nlm.nih.gov/8594255/
Michel M.C. et al. Neuropeptide Y and pancreatic polypeptide receptors. Pharmacological Reviews, 1998.
https://pubmed.ncbi.nlm.nih.gov/9597167/
Balasubramaniam A. Pancreatic polypeptide and related peptides. Endocrine Reviews, 2003.
https://pubmed.ncbi.nlm.nih.gov/12700199/
Keywords: PE-22-28, Pancreatic Polypeptide Fragment, PP(22–28), Y-Receptor Peptide, Synthetic Peptide
