- OP Labs formerly Oxford Peptides
- Batch HPLC tested at 99%+ purity
- Store frozen long term or in fridge when ready to be used
- Sold for research purposes only
- Contact us for Wholesale Orders
Download COA here: Vesugen_20mg.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.
Vesugen
Synonyms / Designations: Vesugen; KED; Lys-Glu-Asp; vascular peptide bioregulator (Khavinson family)
Amino Acid Sequence: Lys-Glu-Asp (KED)
CAS Number: N/A
Molecular Formula: C15H26N4O8
Molecular Weight: 390.39 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Pack Size: 20 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Vesugen (KED) is studied in vitro as a vascular / endothelium-directed short-peptide probe. In organotypic and dissociated cell cultures it has been reported to stimulate the proliferation marker Ki-67 (which declines with age) and to reduce apoptosis (decreased p53), used experimentally to study endothelial cell renewal and vascular-tissue gene-expression programmes.
Within the Khavinson model it is a tool for probing chromatin-level transcriptional regulation in vascular and neuroimmunoendocrine cell systems, including comparative young-versus-old culture studies. Observed effects depend on concentration, model system and exposure conditions.
Applications in Research
- In-vitro endothelial / vascular cell proliferation and apoptosis-marker studies
- Neuroimmunoendocrine organotypic-culture gene-expression research
- Preclinical models of vascular aging (cell culture and rodent)
- Reference probe for short-peptide transcriptional regulation
Specifications Summary
| Parameter | Typical Value / Range |
|---|---|
| Purity (HPLC) | ≥ 99 % |
| Appearance | White to off-white lyophilised powder |
| Molecular Weight | 390.39 g/mol |
| Peptide Type | Synthetic tripeptide bioregulator (Khavinson cytogen family; vascular) |
| Solubility | Water, buffered aqueous solutions |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 20 mg (total) |
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic
- Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
- Avoid vigorous agitation during dissolution
- Filter sterilize if required (e.g. 0.22 µm) prior to use
- Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
- Avoid repeated freeze–thaw cycles
Precautions & Notes
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Appropriate experimental controls are recommended
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Chalisova NI, Lopatina NG, Khavinson VKh, et al. Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells. Bull Exp Biol Med. 2012;153(4):569-572.
https://link.springer.com/article/10.1007/s10517-012-1768-7
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
PubChem Compound Summary, CID 87571363 (Lys-Glu-Asp).
https://pubchem.ncbi.nlm.nih.gov/compound/87571363
Keywords: Vesugen, KED, vascular peptide bioregulator, synthetic tripeptide
