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Download COA here: PEG-MGF.pdf
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PEG-MGF

Synonyms / Designations: PEG-MGF, Pegylated Mechano Growth Factor, PEGylated IGF-1 Ec splice variant, PEG-IGF-1 Ec
CAS Number: 108174-48-7
Molecular Formula: C121H200N42O39 
Molar Weight:~2867.2 g/mol
Peptide / Protein Composition: Mechano Growth Factor (IGF-1 Ec splice variant) covalently conjugated to polyethylene glycol (PEG)
Classification: Pegylated growth factor peptide; IGF-1–derived analogue
Purity: ≥ 99 % (HPLC / SEC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 2mg
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

PEG-MGF is a pegylated derivative of Mechano Growth Factor (MGF), a splice variant of insulin-like growth factor-1 (IGF-1) associated with mechanical stress–responsive signalling in muscle and other tissues. PEGylation is employed to modify physicochemical properties such as stability and resistance to enzymatic degradation in experimental systems.

In biochemical and cellular research models, PEG-MGF is used to investigate IGF-1 receptor–related signalling, satellite cell activation pathways, and growth factor–mediated intracellular responses. Experimental studies focus on receptor interaction dynamics, downstream signalling cascades, and comparative behaviour relative to non-pegylated IGF-1 variants. Observed effects are dependent on experimental design, concentration, and model system, and are used to explore signalling mechanisms rather than defined physiological or clinical outcomes.

Applications in Research

• Investigation of IGF-1–related signalling and muscle mechanotransduction pathways
• Study of growth factor stability and PEGylation effects in vitro
• Comparative research involving IGF-1 splice variants and modified peptides
• Use as a reference compound in growth factor and peptide modification studies

Handling, Reconstitution & Stability

• Handle using appropriate peptide-handling procedures
• Reconstitute in sterile water or suitable buffered aqueous solution
• Gently swirl to dissolve; do not vortex
• Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at –20 °C (or lower)
• Avoid repeated freeze–thaw cycles

Specifications Summary

Purity: Manufactured to specification (research grade)
Appearance: White to off-white lyophilised powder
Peptide Type: Pegylated MGF (IGF-1 Ec analogue)
Molar Weight:~2867.2 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: Typically 2 mg

Precautions & Notes

• Experimental behaviour of PEG-MGF is influenced by receptor expression, concentration, and model system
• PEGylation may alter receptor binding kinetics and intracellular signalling profiles
• Buffer composition and pH may affect peptide stability
• Appropriate controls are recommended to distinguish PEG-related effects from peptide-specific activity
• Intended strictly for laboratory research use; not for human or veterinary application

References

Goldspink G. Gene expression in muscle in response to exercise. Journal of Muscle Research and Cell Motility, 2003.
https://pubmed.ncbi.nlm.nih.gov/14609023/

Matheny R.W. et al. Insulin-like growth factor-I splice variants and muscle growth. American Journal of Physiology, 2010.
https://pubmed.ncbi.nlm.nih.gov/20668872/

Philippou A. et al. IGF-1 isoforms and muscle regeneration. In Vivo, 2007.
https://pubmed.ncbi.nlm.nih.gov/17354613/

Keywords: PEG-MGF, Mechano Growth Factor, IGF-1 Ec, Pegylated Growth Factor, Muscle Signalling Peptide, Research Peptide