• OP Labs formerly Oxford Peptides
• HPLC tested at 99%+ purity
• Store frozen long term or in fridge when ready to be used
• Sold for research purposes only
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Download COA here: SNAP-8_COA.pdf
Please note: if you have a different Batch ID please contact us for the latest COA.

Argireline (SNAP-8)

Synonyms / Designations: SNAP-8, Acetyl Octapeptide-3, SNAP-25 analogue peptide
CAS Number: 868844-74-0
Molecular Formula: C41H70N16O16
Molar Weight: 1075.16 g/mol
Peptide Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Peptide Classification: Synthetic octapeptide; SNAP-25 analogue
Purity: ≥ 99 % (HPLC / SEC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 10 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

SNAP-8 is a synthetic octapeptide designed as an extension of SNAP-25–derived peptide fragments. In biochemical and cellular research systems, SNAP-8 is studied for its interaction with components of the SNARE complex involved in vesicle fusion and neurotransmitter release.

Experimental investigations examine peptide–protein interactions, modulation of synaptic signalling, and comparative activity relative to shorter SNAP-derived peptides. Observed effects are dependent on experimental design, concentration, and model system and are used to explore peptide-mediated signalling mechanisms rather than defined biological or physiological outcomes.

Applications in Research

• Investigation of SNARE-complex interactions and synaptic signalling
• Study of peptide effects on neurotransmitter release mechanisms
• In vitro testing of cosmetic peptide actives
• Use as a reference peptide in neuromuscular signalling research

Handling, Reconstitution & Stability

• Reconstitute in sterile water or appropriate buffered aqueous solution
• Avoid vigorous agitation during dissolution
• Aliquot and store reconstituted solutions at –20 °C
• Avoid repeated freeze–thaw cycles

Specifications Summary

Purity: Manufactured to specification
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic octapeptide
Molecular Weight: 1075.16 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 10 mg

Precautions & Notes

• Experimental behaviour is dependent on concentration and model system
• Peptide stability may be influenced by pH and buffer composition
• Intended strictly for laboratory research use; not for human or veterinary application

References

PubChem. Acetyl Octapeptide-3 (SNAP-8) compound summary.
https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-octapeptide-3

NamSiang. SNAP-8 peptide (Acetyl Octapeptide-3) research and mechanism overview.
https://namsiang.com/en/product/lptr-077-es-99/

Advanced ChemTech. Acetyl Octapeptide-3 (SNAP-8) peptide technical listing (CAS 868844-74-0).
https://advancedchemtech.com/product/acetyl-octapeptide-3-snap-8/

MolChanges. SNAP-8 peptide mechanism and SNARE complex interaction overview.
https://molchanges.com/snap-8

ChemicalBook. Acetyl Octapeptide-3 (SNAP-8): description and mechanism of action.
https://www.chemicalbook.com/article/an-effective-anti-wrinkle-substance-acetyl-octapeptide-3.htm

Keywords: SNAP-8, Acetyl Octapeptide-3, SNARE-modulating peptide, Neurocosmetic peptide, Anti-wrinkle peptide, Cosmetic signal peptide, Topical peptide active, Synthetic octapeptide