OP Labs IGF-1 LR3 1mg research peptide lyophilized powder in glass vial
OP Labs research peptides
quality consistency 99% purity shipped from freezer 24 month shelf life
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£31.15 with offer

IGF1-LR3 1mg

£44.50

IGF-1 LR3 is a specialised research peptide developed for advanced scientific investigation of insulin-like growth factor receptor (IGF-1R) signalling, growth factor–mediated pathways, and downstream intracellular regulatory mechanisms.

OP Labs formerly Oxford Peptides
Batch tested Purity: ≥ 99 % (HPLC, typical)
CAS Number: 946870-92-4
Molecular Formula: C400H625N111O115S9

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(127 customer reviews)

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OP Labs IGF-1 LR3 1mg research peptide lyophilized powder in glass vial
IGF1-LR3 1mg
£44.50

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

  • OP Labs formerly Oxford Peptides
  • Batch HPLC tested at 99%+ purity
  • Store frozen long term or in fridge when ready to be used
  • Sold for research purposes only
  • Contact us for Wholesale Orders

Download COA here: IGF1_LR3_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

IGF-1 LR3

Synonyms / Designations: IGF-1 LR3, Long Arg³ IGF-1, Insulin-Like Growth Factor-1 LR3, Recombinant IGF-1 analogue
CAS Number: 946870-92-4
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
Peptide Classification: Synthetic analogue of insulin-like growth factor-1 (IGF-1)
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 1 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

IGF-1 LR3 is a synthetic analogue of human insulin-like growth factor-1 (IGF-1) incorporating an arginine substitution at position 3 and an extended N-terminal sequence. These structural modifications reduce affinity for endogenous IGF binding proteins, resulting in altered stability and interaction characteristics in experimental systems compared to native IGF-1.

In biochemical and cellular research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signalling cascades associated with growth factor–mediated pathways. Research studies commonly examine receptor binding behaviour, downstream signalling kinetics, and comparative responses relative to native IGF-1. Observed molecular effects are dependent on experimental design, concentration, and model system and are used to investigate IGF-1 receptor signalling rather than defined biological or physiological outcomes.

Applications in Research

  • As a molecular tool for studying IGF-1 receptor binding and activation dynamics
  • Investigation of growth factor–mediated intracellular signalling pathways
  • In vitro studies comparing modified and native IGF-1 analogues
  • Use as a reference compound in endocrine and peptide signalling research

Handling, Reconstitution & Stability

  • Weigh under dry conditions; peptide is hygroscopic
  • Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
  • Avoid vigorous agitation during dissolution
  • Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
  • Aliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradation
  • Avoid repeated freeze–thaw cycles

Specifications Summary

ParameterTypical Value / Range
Purity (HPLC)≥ 99 %
AppearanceWhite to off-white lyophilised powder
Molecular Weight~9117.5 g/mol
Peptide TypeSynthetic IGF-1 analogue
SolubilityWater, buffered aqueous solutions
Storage–20 °C, desiccated, dark
Pack Size1 mg

Precautions & Notes

  • Experimental behaviour of IGF-1 LR3 is influenced by receptor expression, concentration, and exposure duration
  • Modified IGF-1 analogues may exhibit signalling profiles distinct from native IGF-1
  • Buffer composition, pH, and ionic strength may affect peptide stability and assay performance
  • Appropriate controls are recommended to distinguish specific from non-specific effects
  • Intended strictly for laboratory research use; not for human or veterinary application

References

Francis G.L. et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. Journal of Molecular Endocrinology, 1992.
https://pubmed.ncbi.nlm.nih.gov/1378742/

Tomas F.M. et al. Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection. Journal of Endocrinology, 1996.
https://pubmed.ncbi.nlm.nih.gov/8708565/

Ballard F.J. et al. Does IGF-I ever act through the insulin receptor? Cytokine & Growth Factor Reviews, 1996.
https://pubmed.ncbi.nlm.nih.gov/8899293/

Keywords: IGF-1 LR3, Long Arg³ IGF-1, Insulin-Like Growth Factor Analogue, Synthetic Growth Factor

127 reviews for IGF1-LR3 1mg

  1. Adam Lane –

  2. alaa s. –

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    Expensive

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  18. Anonymous –

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    never got my package

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  80. Khaled S. –

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