- OP Labs formerly Oxford Peptides
- Batch HPLC tested at 99%+ purity
- Store frozen long term or in fridge when ready to be used
- Sold for research purposes only
- Contact us for Wholesale Orders
Download COA here: Ovagen_20mg.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.
Ovagen
Synonyms / Designations: Ovagen; EDL; Glu-Asp-Leu; hepatic / GI peptide bioregulator (Khavinson family)
Amino Acid Sequence: Glu-Asp-Leu (EDL)
CAS Number: N/A
Molecular Formula: C15H25N3O8
Molecular Weight: 375.38 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Pack Size: 20 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Ovagen (EDL) is studied in vitro as a short tissue-specific peptide probe for hepatic and gastrointestinal epithelial signalling. In experimental models it is proposed to enter cells and act at the chromatin/transcriptional level, modulating expression of genes associated with hepatocyte proliferation and epithelial homeostasis.
Within the Khavinson “peptide regulation of gene expression” framework, EDL serves as a reference compound for testing tissue-selective effects on proliferation/apoptosis markers (e.g. Ki-67, p53) in cultures derived from young versus aged tissue. It is a molecular probe; observed effects depend on concentration, model system and exposure conditions.
Applications in Research
- In-vitro study of hepatocyte / GI-epithelial gene-expression regulation in organotypic cultures
- Comparative tissue-specificity screening across the Khavinson bioregulator panel
- Preclinical models of hepatic stress / regeneration (cell-culture and rodent)
- Reference probe for short-peptide chromatin / transcription studies
Specifications Summary
| Parameter | Typical Value / Range |
|---|---|
| Purity (HPLC) | ≥ 99 % |
| Appearance | White to off-white lyophilised powder |
| Molecular Weight | 375.38 g/mol |
| Peptide Type | Synthetic linear tripeptide bioregulator (Khavinson cytogen family) |
| Solubility | Water, buffered aqueous solutions |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 20 mg (total) |
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic
- Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
- Avoid vigorous agitation during dissolution
- Filter sterilize if required (e.g. 0.22 µm) prior to use
- Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
- Avoid repeated freeze–thaw cycles
Precautions & Notes
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Appropriate experimental controls are recommended
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Khavinson VKh. Peptides and ageing. Neuro Endocrinol Lett. 2002;23(Suppl 3):11-144.
https://pubmed.ncbi.nlm.nih.gov/12374906/
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
PubChem Compound Summary, CID 444128 (Glu-Asp-Leu).
https://pubchem.ncbi.nlm.nih.gov/compound/444128
Keywords: Ovagen, EDL, hepatic peptide bioregulator, synthetic tripeptide
